InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BCL10

Summary

InnateDB Gene

IDBG-100044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL10

Gene Name

B-cell CLL/lymphoma 10

Synonyms

c-E10; CARMEN; CIPER; CLAP; mE10

Species

Homo sapiens

Ensembl Gene

ENSG00000142867

Encoded Proteins

IDBP-100048

B-cell CLL/lymphoma 10

IDBP-808398

B-cell CLL/lymphoma 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18806265

BCL10 and MALT1 are essential mediators of NF-kappaB activation in response to the triggering of a diverse array of transmembrane receptors, including antigen receptors.

PMID 17540779

BCL10 mediates LPS-induced activation of NF-kappaB and IL8 in human intestinal epithelial cells.

Entrez Gene

Summary

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:85266248-85277090

Strand

Reverse strand

Band

p22.3

Transcripts

ENST00000370580	ENSP00000359612
ENST00000620248	ENSP00000480561

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	100 [view]
Protein-Protein	99 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0008134	transcription factor binding
GO:0019209	kinase activator activity
GO:0019899	enzyme binding
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0043130	ubiquitin binding
GO:0043422	protein kinase B binding
GO:0043621	protein self-association
GO:0051059	NF-kappaB binding

Biological Process

GO:0001783	B cell apoptotic process
GO:0001843	neural tube closure
GO:0002224	toll-like receptor signaling pathway
GO:0002237	response to molecule of bacterial origin
GO:0002250	adaptive immune response
GO:0002906	negative regulation of mature B cell apoptotic process
GO:0006968	cellular defense response
GO:0008219	cell death
GO:0009620	response to fungus
GO:0016064	immunoglobulin mediated immune response
GO:0031398	positive regulation of protein ubiquitination
GO:0032094	response to food
GO:0032765	positive regulation of mast cell cytokine production
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042109	lymphotoxin A biosynthetic process
GO:0042226	interleukin-6 biosynthetic process
GO:0042327	positive regulation of phosphorylation
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050852	T cell receptor signaling pathway
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051259	protein oligomerization
GO:0051260	protein homooligomerization
GO:0070231	T cell apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005829	cytosol
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0032449	CBM complex
GO:0042101	T cell receptor complex
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0046696	lipopolysaccharide receptor complex
GO:0048471	perinuclear region of cytoplasm