Homo sapiens Gene: BCL10
Summary
InnateDB Gene IDBG-100044.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL10
Gene Name B-cell CLL/lymphoma 10
Synonyms c-E10; CARMEN; CIPER; CLAP; mE10
Species Homo sapiens
Ensembl Gene ENSG00000142867
Encoded Proteins
B-cell CLL/lymphoma 10
B-cell CLL/lymphoma 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
BCL10 and MALT1 are essential mediators of NF-kappaB activation in response to the triggering of a diverse array of transmembrane receptors, including antigen receptors.
BCL10 mediates LPS-induced activation of NF-kappaB and IL8 in human intestinal epithelial cells.
Entrez Gene
Summary This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:85266248-85277090
Strand Reverse strand
Band p22.3
Transcripts
ENST00000370580 ENSP00000359612
ENST00000620248 ENSP00000480561
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 100 [view]
Protein-Protein 99 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008134 transcription factor binding
GO:0019209 kinase activator activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0043130 ubiquitin binding
GO:0043422 protein kinase B binding
GO:0043621 protein self-association
GO:0051059 NF-kappaB binding
Biological Process
GO:0001783 B cell apoptotic process
GO:0001843 neural tube closure
GO:0002224 toll-like receptor signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002250 adaptive immune response
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0006968 cellular defense response
GO:0008219 cell death
GO:0009620 response to fungus
GO:0016064 immunoglobulin mediated immune response
GO:0031398 positive regulation of protein ubiquitination
GO:0032094 response to food
GO:0032765 positive regulation of mast cell cytokine production
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042109 lymphotoxin A biosynthetic process
GO:0042226 interleukin-6 biosynthetic process
GO:0042327 positive regulation of phosphorylation
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045416 positive regulation of interleukin-8 biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050852 T cell receptor signaling pathway
GO:0050856 regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0070231 T cell apoptotic process
GO:0071260 cellular response to mechanical stimulus
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005881 cytoplasmic microtubule
GO:0005886 plasma membrane
GO:0032449 CBM complex
GO:0042101 T cell receptor complex
GO:0043234 protein complex
GO:0045121 membrane raft
GO:0046696 lipopolysaccharide receptor complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
TCR pathway
BCR pathway
REACTOME
Downstream TCR signaling pathway
Activation of NF-kappaB in B cells pathway
FCERI mediated NF-kB activation pathway
TCR signaling pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Adaptive Immune System pathway
Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
KEGG
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
INOH
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
PID NCI
TCR signaling in na´ve CD8+ T cells
TCR signaling in na´ve CD4+ T cells
BCR signaling pathway
Canonical NF-kappaB pathway
Cross-References
SwissProt O95999
TrEMBL
UniProt Splice Variant
Entrez Gene 8915
UniGene Hs.193516 Hs.618972
RefSeq NM_003921
HUGO HGNC:989
OMIM 603517
CCDS CCDS704
HPRD 04625
IMGT
EMBL AF057700 AF082283 AF097732 AF100338 AF105066 AF127386 AF134395 AJ006288 AK291346 AL590113 BC053617 CH471097
GenPept AAC99767 AAD15800 AAD16428 AAD24918 AAD32597 AAD39147 AAF06894 AAH53617 BAF84035 CAA06955 CAH71557 EAW73208
RNA Seq Atlas 8915