Version 5.4
Homo sapiens Protein: FRRS1
Summary
InnateDB Protein IDBP-100448.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FRRS1
Protein Name ferric-chelate reductase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000287474
InnateDB Gene IDBG-100446 (FRRS1)
Protein Structure
UniProt Annotation
Function Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000293 ferric-chelate reductase activity
GO:0046872 metal ion binding
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR002861 Reeler domain
IPR005018 DOMON domain
IPR006593 Cytochrome b561/ferric reductase transmembrane
PFAM PF02014
PF03351
PRINTS
PIRSF
SMART SM00664
SM00665
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZNA5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 391059
UniGene Hs.454779
RefSeq NP_001013682
HUGO HGNC:27622
OMIM 611578
CCDS CCDS30780
HPRD 18403
IMGT
EMBL AK131302 AL451051 CH471097
GenPept BAD18470 EAW72988

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca