InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RTCA

Summary

InnateDB Protein

IDBP-100508.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RTCA

Protein Name

RNA terminal phosphate cyclase domain 1

Synonyms

RPC; RTC1; RTCD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000260563

InnateDB Gene

IDBG-100504 (RTCA)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

Subcellular Localization

Nucleus, nucleoplasm.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003963	RNA-3'-phosphate cyclase activity
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006396

RNA processing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR013791 RNA 3\'-terminal phosphate cyclase, insert domain
IPR013792 RNA 3\'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
IPR017770 RNA 3\'-terminal phosphate cyclase type 1
IPR023797 RNA 3\'-terminal phosphate cyclase domain

PFAM

PF05189
PF01137

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00442

PhosphoSite