InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNA10

Summary

InnateDB Protein

IDBP-100989.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNA10

Protein Name

potassium voltage-gated channel, shaker-related subfamily, member 10

Synonyms

Kcn1; Kv1.8;

Species

Homo sapiens

Ensembl Protein

ENSP00000358786

InnateDB Gene

IDBG-100987 (KCNA10)

Protein Structure

UniProt Annotation

Function

Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. {ECO:0000269PubMed:10836990}.

Subcellular Localization

Membrane {ECO:0000269PubMed:10836990}; Multi-pass membrane protein {ECO:0000269PubMed:10836990}.

Disease Associations

Tissue Specificity

Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells. {ECO:0000269PubMed:12444201}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005221	intracellular cyclic nucleotide activated cation channel activity
GO:0005251	delayed rectifier potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003972 Potassium channel, voltage dependent, Kv1
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain
IPR013122 Polycystin cation channel, PKD1/PKD2

PFAM

PF02214
PF00520
PF07885
PF08016

PRINTS

PR00169
PR01491
PR01496

PIRSF

SMART

SM00225

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt