Version 5.4
Homo sapiens Protein: POLDIP3
Summary
InnateDB Protein IDBP-10099.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLDIP3
Protein Name polymerase (DNA-directed), delta interacting protein 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000252115
InnateDB Gene IDBG-10097 (POLDIP3)
Protein Structure
UniProt Annotation
Function Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex. {ECO:0000269PubMed:18423201, ECO:0000269PubMed:22928037}.
Subcellular Localization Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0016973 poly(A)+ mRNA export from nucleus
GO:0045727 positive regulation of translation
Cellular Component
GO:0000346 transcription export complex
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BY77
PhosphoSite PhosphoSite-Q9BY77
TrEMBL Q96DI9
UniProt Splice Variant
Entrez Gene 84271
UniGene Hs.743592
RefSeq NP_115687
HUGO HGNC:23782
OMIM 611520
CCDS CCDS14038
HPRD 17875
IMGT
EMBL AB055760 AK291623 AK291774 AL160111 AL160112 AY422990 BC001488 BC049840 BC056912 BC095411 CR456456 DQ887818 Z93241
GenPept AAH01488 AAH49840 AAH56912 AAH95411 AAQ94604 ABI74675 BAB33368 BAF84312 BAF84463 CAB77058 CAB77059 CAG30342 CAI19835 CAQ08413

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca