Version 5.4
Homo sapiens Protein: ADORA3
Summary
InnateDB Protein IDBP-101078.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADORA3
Protein Name adenosine A3 receptor
Synonyms A3AR; AD026; bA552M11.5;
Species Homo sapiens
Ensembl Protein ENSP00000358730
InnateDB Gene IDBG-101074 (ADORA3)
Protein Structure
UniProt Annotation
Function Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001609 G-protein coupled adenosine receptor activity
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0001973 adenosine receptor signaling pathway
GO:0002553 histamine secretion by mast cell
GO:0002687 positive regulation of leukocyte migration
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0008016 regulation of heart contraction
GO:0009611 response to wounding
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0043306 positive regulation of mast cell degranulation
GO:0050729 positive regulation of inflammatory response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0070257 positive regulation of mucus secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0042629 mast cell granule
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000466 Adenosine A3 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR00555
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P33765
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 140
UniGene Hs.281342
RefSeq NP_065734
HUGO HGNC:268
OMIM 600445
CCDS CCDS838
HPRD 12424
IMGT
EMBL AL390195 AY011231 AY136749 AY358644 BC029831 L20463 L22607 L77729 L77730 X76981
GenPept AAA16365 AAA35949 AAB02790 AAG35155 AAH29831 AAN01275 AAQ89007 CAA54288 CAC36045 CAM21993

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca