InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHGDH

Summary

InnateDB Protein

IDBP-101526.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHGDH

Protein Name

phosphoglycerate dehydrogenase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000358415

InnateDB Gene

IDBG-101522 (PHGDH)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	81 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004617	phosphoglycerate dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287	NAD binding

Biological Process

GO:0006564	L-serine biosynthetic process
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
IPR006236 D-3-phosphoglycerate dehydrogenase
IPR029009 Allosteric substrate binding domain

PFAM

PF00389
PF02826

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-