InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADAM30

Summary

InnateDB Protein

IDBP-101543.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAM30

Protein Name

ADAM metallopeptidase domain 30

Synonyms

svph4;

Species

Homo sapiens

Ensembl Protein

ENSP00000358407

InnateDB Gene

IDBG-101541 (ADAM30)

Protein Structure

UniProt Annotation

Function

May be involved in spermatogenesis and fertilization.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed specifically in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0007338	single fertilization
GO:0007339	binding of sperm to zona pellucida
GO:0032504	multicellular organism reproduction

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UKF2

PhosphoSite

PhosphoSite-Q9UKF2

TrEMBL

UniProt Splice Variant

Entrez Gene

11085

UniGene

Hs.642464

RefSeq

NP_068566

HUGO

HGNC:208

OMIM

604779

CCDS

CCDS907

HPRD

05307

IMGT

EMBL

AF171932 AF171933 AK292483 AL359752 AY358734

GenPept

AAF03780 AAF03781 AAQ89096 BAF85172 CAI18978