InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FCGR1B

Summary

InnateDB Protein

IDBP-101567.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FCGR1B

Protein Name

Fc fragment of IgG, high affinity Ib, receptor (CD64)

Synonyms

CD64b; IGFRB;

Species

Homo sapiens

Ensembl Protein

ENSP00000358391

InnateDB Gene

IDBG-101565 (FCGR1B)

Protein Structure

UniProt Annotation

Function

May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response. {ECO:0000269PubMed:1430234, ECO:0000269PubMed:9881690}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:1430234}; Single-pass type I membrane protein {ECO:0000269PubMed:1430234}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019763	immunoglobulin receptor activity
GO:0019864	IgG binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006955	immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0038093	Fc receptor signaling pathway
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0031901	early endosome membrane