Homo sapiens Gene: FCGR1B
Summary
InnateDB Gene IDBG-101565.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCGR1B
Gene Name Fc fragment of IgG, high affinity Ib, receptor (CD64)
Synonyms CD64b; IGFRB;
Species Homo sapiens
Ensembl Gene ENSG00000198019
Encoded Proteins
Fc fragment of IgG, high affinity Ib, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The gene represents one of three related immunoglobulin gamma Fc receptor genes located on chromosome 1. This family member lacks the transmembrane and coiled-coiled domains found in other family members and is thought to be a pseudogene of Fc-gamma-receptor 1A. [provided by RefSeq, Apr 2009] Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Three distinct, but closely related classes of receptors that bind the Fc portion of IgG have been identified (Fcgamma RI, II and III). The FcgammaRI family consists of three closely related genes termed A, B, and C. This gene encodes the low affinity FcgammaRIB receptor that may play an important role in humoral immune response. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:121087345-121096310
Strand Forward strand
Band p11.2
Transcripts
ENST00000369384 ENSP00000358391
ENST00000369383 ENSP00000358390
ENST00000369178 ENSP00000481411
ENST00000466915
ENST00000472543 ENSP00000479641
ENST00000471609
ENST00000616817 ENSP00000478655
ENST00000615565
ENST00000623603 ENSP00000485498
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019763 immunoglobulin receptor activity
GO:0019864 IgG binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006955 immune response
GO:0019221 cytokine-mediated signaling pathway
GO:0038093 Fc receptor signaling pathway
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0060333 interferon-gamma-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031901 early endosome membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Interferon gamma signaling pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001004340 NM_001017986 NM_001244910
HUGO
OMIM
CCDS CCDS72844 CCDS72845 CCDS72846
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas