InnateDB Protein
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IDBP-101644.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PDE4DIP
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Protein Name
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phosphodiesterase 4D interacting protein
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Synonyms
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CMYA2; MMGL;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000358363
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InnateDB Gene
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IDBG-101638 (PDE4DIP)
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Protein Structure
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Function |
May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:11374908}. Nucleus {ECO:0000269PubMed:11374908}.
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Disease Associations |
Note=A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP- PDGFRB fusion protein.
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Tissue Specificity |
Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta. {ECO:0000269PubMed:11374908}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
54
[view]
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Protein-Protein |
52
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR012943
Spindle associated
IPR016024
Armadillo-type fold
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PFAM |
PF07989
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5VU43
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PhosphoSite |
PhosphoSite-Q5VU43
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TrEMBL |
I1VE15
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UniProt Splice Variant |
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Entrez Gene |
9659
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UniGene |
Hs.641529
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RefSeq |
NP_001185763
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HUGO |
HGNC:15580
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OMIM |
608117
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CCDS |
CCDS72892
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HPRD |
10482
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IMGT |
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EMBL |
AB007923
AB007946
AB042555
AB042556
AB042557
AB042558
AL138791
AL138796
AL590452
AL831815
AL832024
AL833273
BC004860
BC025406
BC078660
BC110294
BC132717
BC152439
CR749273
DA900724
JQ388960
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GenPept |
AAH04860
AAH25406
AAH78660
AAI10295
AAI32718
AAI52440
AFI41825
BAA32299
BAA32322
BAB17759
BAB17760
BAB17761
BAB17762
CAD38529
CAD89923
CAD91152
CAH18128
CAH72521
CAH72522
CAH72523
CAH72524
CAH72525
CAH72526
CAH72527
CAH72528
CAI22527
CAI22822
CAI22823
CAI22824
CAI22825
CAI22826
CAI22827
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