Version 5.4
Homo sapiens Protein: PDE4DIP
Summary
InnateDB Protein IDBP-101662.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE4DIP
Protein Name phosphodiesterase 4D interacting protein
Synonyms CMYA2; MMGL;
Species Homo sapiens
Ensembl Protein ENSP00000358353
InnateDB Gene IDBG-101638 (PDE4DIP)
Protein Structure
UniProt Annotation
Function May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. {ECO:0000250}.
Subcellular Localization Golgi apparatus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:11374908}. Nucleus {ECO:0000269PubMed:11374908}.
Disease Associations Note=A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD) associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP- PDGFRB fusion protein.
Tissue Specificity Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta. {ECO:0000269PubMed:11374908}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
Experimentally validated
Total 54 [view]
Protein-Protein 52 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
Biological Process
GO:0043623 cellular protein complex assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0030016 myofibril
Protein Structure and Domains
PDB ID
InterPro IPR012943 Spindle associated
PFAM PF07989
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5VU43
PhosphoSite PhosphoSite-Q5VU43
TrEMBL
UniProt Splice Variant
Entrez Gene 9659
UniGene Hs.641529
RefSeq NP_001182189
HUGO HGNC:15580
OMIM 608117
CCDS CCDS72893
HPRD 10482
IMGT
EMBL AB007923 AB007946 AB042555 AB042556 AB042557 AB042558 AL138791 AL138796 AL590452 AL831815 AL832024 AL833273 BC004860 BC025406 BC078660 BC110294 BC132717 BC152439 CR749273 DA900724
GenPept AAH04860 AAH25406 AAH78660 AAI10295 AAI32718 AAI52440 BAA32299 BAA32322 BAB17759 BAB17760 BAB17761 BAB17762 CAD38529 CAD89923 CAD91152 CAH18128 CAH72521 CAH72522 CAH72523 CAH72524 CAH72525 CAH72526 CAH72527 CAH72528 CAI22527 CAI22822 CAI22823 CAI22824 CAI22825 CAI22826 CAI22827

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca