InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRKAB2

Summary

InnateDB Protein

IDBP-101808.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAB2

Protein Name

protein kinase, AMP-activated, beta 2 non-catalytic subunit

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000254101

InnateDB Gene

IDBG-101806 (PRKAB2)

Protein Structure

UniProt Annotation

Function

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.

Experimentally validated
Total	92 [view]
Protein-Protein	89 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004679	AMP-activated protein kinase activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0006853	carnitine shuttle
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0042304	regulation of fatty acid biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0061024	membrane organization