InnateDB Protein
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IDBP-101808.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRKAB2
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Protein Name
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protein kinase, AMP-activated, beta 2 non-catalytic subunit
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000254101
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InnateDB Gene
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IDBG-101806 (PRKAB2)
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Protein Structure
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Function |
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
92
[view]
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Protein-Protein |
89
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006828
5-AMP-activated protein kinase, beta subunit, interaction domain
IPR014756
Immunoglobulin E-set
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PFAM |
PF04739
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PRINTS |
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PIRSF |
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SMART |
SM01010
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TIGRFAMs |
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Modification |
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SwissProt |
O43741
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PhosphoSite |
PhosphoSite-O43741
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5565
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UniGene |
Hs.598065
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RefSeq |
NP_005390
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HUGO |
HGNC:9379
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OMIM |
602741
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CCDS |
CCDS925
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HPRD |
04117
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IMGT |
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EMBL |
AF504538
AF504539
AF504540
AF504541
AF504542
AF504543
AJ224538
AK292820
AL356378
BC053610
CH471223
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GenPept |
AAH53610
AAM74153
BAF85509
CAA12030
CAH72644
EAW50945
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