Version 5.4
Homo sapiens Protein: BCL2L13
Summary
InnateDB Protein IDBP-1020.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCL2L13
Protein Name BCL2-like 13 (apoptosis facilitator)
Synonyms BCL-RAMBO; Bcl2-L-13; MIL1;
Species Homo sapiens
Ensembl Protein ENSP00000318883
InnateDB Gene IDBG-1018 (BCL2L13)
Protein Structure
UniProt Annotation
Function May promote the activation of caspase-3 and apoptosis.
Subcellular Localization Isoform 2: Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000305}.Isoform 1: Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitous, with the highest levels of expression in heart, placenta and pancreas.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0042981 regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID
InterPro IPR002475 Bcl2-like
IPR026298 Blc2 family
PFAM PF00452
PRINTS PR01862
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BXK5
PhosphoSite PhosphoSite-Q9BXK5
TrEMBL B2RB43
UniProt Splice Variant
Entrez Gene 23786
UniGene Hs.743849
RefSeq NP_056182
HUGO HGNC:17164
OMIM
CCDS CCDS13746
HPRD 09822
IMGT
EMBL AC006285 AF146568 AF183411 AF246665 AF325209 AK056248 AK314489 AL133029 BC007658 BC016037 CH471193 CR456521
GenPept AAF03602 AAG09680 AAH07658 AAH16037 AAK15150 AAK27358 BAG37090 BAG51659 CAB61361 CAG30407 EAW57768

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca