Homo sapiens Protein: SEMA6C
Summary
InnateDB Protein IDBP-102293.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA6C
Protein Name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Synonyms m-SemaY; m-SemaY2; SEMAY;
Species Homo sapiens
Ensembl Protein ENSP00000357910
InnateDB Gene IDBG-102291 (SEMA6C)
Protein Structure
UniProt Annotation
Function Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. {ECO:0000269PubMed:12110693}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity In adult tissues, expressed only in skeletal muscle. {ECO:0000269PubMed:12110693}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001627 Sema domain
IPR002165 Plexin
IPR016201 Plexin-like fold
PFAM PF01403
PF01437
PRINTS
PIRSF
SMART SM00630
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3T2
PhosphoSite PhosphoSite-Q9H3T2
TrEMBL Q9UFI1
UniProt Splice Variant
Entrez Gene 10500
UniGene Hs.713961
RefSeq NP_112175
HUGO HGNC:10740
OMIM 609294
CCDS CCDS984
HPRD 10220
IMGT
EMBL AB022434 AB058772 AF055020 AF339152 AF339153 AF339154 AL122064 AL592424 CH471121
GenPept AAC09365 AAL72098 AAL72099 AAL72100 BAB20670 BAB47498 CAB59243 CAI16376 CAI16377 CAI16378 EAW53470 EAW53472