Homo sapiens Protein: SEMA6C
Summary
InnateDB Protein IDBP-102295.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEMA6C
Protein Name sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Synonyms m-SemaY; m-SemaY2; SEMAY;
Species Homo sapiens
Ensembl Protein ENSP00000357909
InnateDB Gene IDBG-102291 (SEMA6C)
Protein Structure
UniProt Annotation
Function Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. {ECO:0000269PubMed:12110693}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity In adult tissues, expressed only in skeletal muscle. {ECO:0000269PubMed:12110693}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001627 Sema domain
IPR002165 Plexin
IPR016201 Plexin-like fold
PFAM PF01403
PF01437
PRINTS
PIRSF
SMART SM00630
SM00423
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H3T2
PhosphoSite PhosphoSite-Q9H3T2
TrEMBL Q9UFI1
UniProt Splice Variant
Entrez Gene 10500
UniGene Hs.713961
RefSeq NP_001171532
HUGO HGNC:10740
OMIM 609294
CCDS CCDS53364
HPRD 10220
IMGT
EMBL AB022434 AB058772 AF339152 AF339153 AF339154 AL122064 AL592424 CH471121
GenPept AAL72098 AAL72099 AAL72100 BAB20670 BAB47498 CAB59243 CAI16376 CAI16377 CAI16378 EAW53470 EAW53472