Version 5.4
Homo sapiens Protein: TNFAIP8L2
Summary
InnateDB Protein IDBP-102302.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFAIP8L2
Protein Name tumor necrosis factor, alpha-induced protein 8-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357906
InnateDB Gene IDBG-102300 (TNFAIP8L2)
Protein Structure
UniProt Annotation
Function Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0050728 negative regulation of inflammatory response
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008477 Protein of unknown function DUF758
PFAM PF05527
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P589
PhosphoSite PhosphoSite-Q6P589
TrEMBL
UniProt Splice Variant
Entrez Gene 79626
UniGene Hs.432360
RefSeq NP_078851
HUGO HGNC:26277
OMIM 612112
CCDS CCDS985
HPRD 08029
IMGT
EMBL AF271774 AF548003 AK027120 AL592424 AL833373 BC063014 CR457375
GenPept AAG44785 AAH63014 AAQ12262 BAB15664 CAG33656 CAI16379 CAI46145

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca