Homo sapiens Gene: TNFAIP8L2
Summary
InnateDB Gene IDBG-102300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFAIP8L2
Gene Name tumor necrosis factor, alpha-induced protein 8-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163154
Encoded Proteins
tumor necrosis factor, alpha-induced protein 8-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TNFAIP8L2 is a negative regulator of innate and adaptive immunity that maintains immune homeostasis by binding to CASP8 and inhibiting nuclear factor kappa B activation while promoting apoptosis.
TNFAIP8L2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway. (Demonstrated in mouse)
TNFAIP8L2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Tnfaip8l2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway.
[Mus musculus] Tnfaip8l2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:151156629-151159749
Strand Forward strand
Band q21.3
Transcripts
ENST00000368910 ENSP00000357906
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0050728 negative regulation of inflammatory response
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q6P589
TrEMBL
UniProt Splice Variant
Entrez Gene 79626
UniGene Hs.432360
RefSeq NM_024575
HUGO HGNC:26277
OMIM 612112
CCDS CCDS985
HPRD 08029
IMGT
EMBL AF271774 AF548003 AK027120 AL592424 AL833373 BC063014 CR457375
GenPept AAG44785 AAH63014 AAQ12262 BAB15664 CAG33656 CAI16379 CAI46145
RNA Seq Atlas 79626