|Homo sapiens Gene: TNFAIP8L2|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||tumor necrosis factor, alpha-induced protein 8-like 2|
tumor necrosis factor, alpha-induced protein 8-like 2
|Useful resources||Stemformatics EHFPI ImmGen|
TNFAIP8L2 is a negative regulator of innate and adaptive immunity that maintains immune homeostasis by binding to CASP8 and inhibiting nuclear factor kappa B activation while promoting apoptosis.
TNFAIP8L2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway. (Demonstrated in mouse)
TNFAIP8L2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection. (Demonstrated in mice)
|InnateDB Annotation from Orthologs|
[Mus musculus] Tnfaip8l2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway.
[Mus musculus] Tnfaip8l2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection.
|Summary||Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.|
|Genomic Location||Chromosome 1:151156629-151159749|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|UniProt Splice Variant|
|EMBL||AF271774 AF548003 AK027120 AL592424 AL833373 BC063014 CR457375|
|GenPept||AAG44785 AAH63014 AAQ12262 BAB15664 CAG33656 CAI16379 CAI46145|
|RNA Seq Atlas||79626|