Version 5.4
Homo sapiens Gene: TNFAIP8L2
Summary
InnateDB Gene IDBG-102300.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFAIP8L2
Gene Name tumor necrosis factor, alpha-induced protein 8-like 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163154
Encoded Proteins
IDBP-102302
tumor necrosis factor, alpha-induced protein 8-like 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18455983
TNFAIP8L2 is a negative regulator of innate and adaptive immunity that maintains immune homeostasis by binding to CASP8 and inhibiting nuclear factor kappa B activation while promoting apoptosis.
PMID 22904303
TNFAIP8L2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway. (Demonstrated in mouse)
PMID 22949657
TNFAIP8L2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22904303
[Mus musculus] Tnfaip8l2 is a negative regulator of immunity that controls innate immunity to RNA by targeting the PI3K-Rac pathway.
PMID 22949657
[Mus musculus] Tnfaip8l2 (TIPE2) serves as a negative regulator of phagocytosis and oxidative burst during infection.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:151156629-151159749
Strand Forward strand
Band q21.3
Transcripts
ENST00000368910 ENSP00000357906
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0050728 negative regulation of inflammatory response
GO:0050868 negative regulation of T cell activation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013707
View Gene Order
ENSBTAG00000020394
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.432360
RefSeq NM_024575
HUGO
OMIM
CCDS CCDS985
HPRD 08029
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca