InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S100A14

Summary

InnateDB Protein

IDBP-102729.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100A14

Protein Name

S100 calcium binding protein A14

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357691

InnateDB Gene

IDBG-102727 (S100A14)

Protein Structure

UniProt Annotation

Function

Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269PubMed:21559403, ECO:0000269PubMed:22032898, ECO:0000269PubMed:22451655}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11944983}.

Disease Associations

Tissue Specificity

Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes. {ECO:0000269PubMed:11944983}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0042379	chemokine receptor binding

Biological Process

GO:0006915	apoptotic process
GO:0032496	response to lipopolysaccharide
GO:0034142	toll-like receptor 4 signaling pathway
GO:0042742	defense response to bacterium
GO:0055074	calcium ion homeostasis
GO:0071624	positive regulation of granulocyte chemotaxis
GO:0090026	positive regulation of monocyte chemotaxis