Version 5.4
Homo sapiens Gene: S100A14
Summary
InnateDB Gene IDBG-102727.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100A14
Gene Name S100 calcium binding protein A14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000189334
Encoded Proteins
IDBP-102729
S100 calcium binding protein A14
IDBP-102731
S100 calcium binding protein A14
IDBP-102735
S100 calcium binding protein A14
IDBP-475566
S100 calcium binding protein A14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153614255-153616986
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368702 ENSP00000357691
ENST00000368701 ENSP00000357690
ENST00000368700
ENST00000344616 ENSP00000340463
ENST00000476873 ENSP00000420296
ENST00000469571
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0042379 chemokine receptor binding
Biological Process
GO:0006915 apoptotic process
GO:0032496 response to lipopolysaccharide
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042742 defense response to bacterium
GO:0055074 calcium ion homeostasis
GO:0071624 positive regulation of granulocyte chemotaxis
GO:0090026 positive regulation of monocyte chemotaxis
Cellular Component
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042306
View Gene Order
ENSBTAG00000021377
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_020672 XM_005245362 XM_006711468
HUGO
OMIM
CCDS CCDS1046
HPRD 10467
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca