InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S100A1

Summary

InnateDB Protein

IDBP-102747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100A1

Protein Name

S100 calcium binding protein A1

Synonyms

S100; S100-alpha; S100A;

Species

Homo sapiens

Ensembl Protein

ENSP00000292169

InnateDB Gene

IDBG-102741 (S100A1)

Protein Structure

UniProt Annotation

Function

Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. {ECO:0000269PubMed:22399290}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044548	S100 protein binding
GO:0048306	calcium-dependent protein binding
GO:0051117	ATPase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0008016	regulation of heart contraction
GO:0021762	substantia nigra development
GO:0035556	intracellular signal transduction
GO:1901387	positive regulation of voltage-gated calcium channel activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016529	sarcoplasmic reticulum
GO:0030018	Z disc
GO:0031430	M band
GO:0031672	A band
GO:0031674	I band
GO:0043005	neuron projection
GO:0043234	protein complex