InnateDB Protein
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IDBP-102754.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHTOP
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Protein Name
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chromatin target of PRMT1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357679
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InnateDB Gene
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IDBG-102750 (CHTOP)
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Protein Structure
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Function |
Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity.
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Subcellular Localization |
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in an erythroid progenitor cell line derived from peripheral blood. {ECO:0000269PubMed:20688955}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
26
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y3Y2
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PhosphoSite |
PhosphoSite-Q9Y3Y2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26097
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UniGene |
Hs.728799
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RefSeq |
NP_001193541
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HUGO |
HGNC:24511
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OMIM |
614206
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CCDS |
CCDS72917
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HPRD |
13163
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IMGT |
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EMBL |
AF261137
AF318362
AL050260
AL162258
AL512704
BC002733
BC059949
BC070027
BC108721
BC120961
BC120962
CH471121
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GenPept |
AAG44673
AAH02733
AAH59949
AAH70027
AAI08722
AAI20962
AAI20963
AAL55869
CAB43362
CAC21650
CAI19678
CAI19679
CAI19680
EAW53290
EAW53295
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