Homo sapiens Protein: KCNN3
Summary
InnateDB Protein IDBP-102979.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNN3
Protein Name potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Synonyms hSK3; KCa2.3; SK3; SKCA3;
Species Homo sapiens
Ensembl Protein ENSP00000354764
InnateDB Gene IDBG-102975 (KCNN3)
Protein Structure
UniProt Annotation
Function Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005516 calmodulin binding
GO:0015269 calcium-activated potassium channel activity
GO:0016286 small conductance calcium-activated potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID
InterPro IPR004178 Calmodulin-binding domain
IPR013099 Two pore domain potassium channel domain
IPR015449 Potassium channel, calcium-activated, SK
PFAM PF02888
PF07885
PF03530
PRINTS PR01451
PIRSF
SMART SM01053
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UGI6
PhosphoSite PhosphoSite-Q9UGI6
TrEMBL
UniProt Splice Variant
Entrez Gene 3782
UniGene
RefSeq NP_740752
HUGO HGNC:6292
OMIM 602983
CCDS CCDS1072
HPRD 04283
IMGT
EMBL AF031815 AF336797 AF438203 AJ251016 AL390204 AL606500 AL954342 AY138900 BC042147 CH471121
GenPept AAC26099 AAH42147 AAK15345 AAL40801 AAN46636 CAB61331 CAH71150 CAH71151 CAH71910 CAH71911 CAH72738 CAH72739 EAW53180 EAW53182