InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNN3

Summary

InnateDB Gene

IDBG-102975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNN3

Gene Name

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

Synonyms

hSK3; KCa2.3; SK3; SKCA3

Species

Homo sapiens

Ensembl Gene

ENSG00000143603

Encoded Proteins

IDBP-102977

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

IDBP-102979

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

IDBP-102981

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

IDBP-810434

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:154697455-154870280

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000271915	ENSP00000271915
ENST00000361147	ENSP00000354764
ENST00000358505	ENSP00000351295
ENST00000618040	ENSP00000481848

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005516	calmodulin binding
GO:0015269	calcium-activated potassium channel activity
GO:0016286	small conductance calcium-activated potassium channel activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030175	filopodium
GO:0031594	neuromuscular junction
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0044297	cell body

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000000794

View Gene Order

ENSBTAG00000018249

Not yet available

Pathways

NETPATH

REACTOME

REACT_75896

Ca2+ activated K+ channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q6JXY2

UniProt Splice Variant

Entrez Gene

3782

UniGene

RefSeq

NM_002249 NM_001204087 NM_170782

HUGO

HGNC:6292

OMIM

602983

CCDS

CCDS30880 CCDS1072 CCDS72928

HPRD

04283

IMGT

EMBL

AF031815 AF336797 AF438203 AJ251016 AL390204 AL606500 AL954342 AY138900 AY258142 BC042147 CH471121

GenPept

AAC26099 AAH42147 AAK15345 AAL40801 AAN46636 AAP45947 CAB61331 CAH71150 CAH71151 CAH71910 CAH71911 CAH72738 CAH72739 EAW53180 EAW53182

RNA Seq Atlas

3782