Version 5.4
Homo sapiens Protein: PMVK
Summary
InnateDB Protein IDBP-102984.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PMVK
Protein Name phosphomevalonate kinase
Synonyms HUMPMKI; PMK; PMKA; PMKASE;
Species Homo sapiens
Ensembl Protein ENSP00000357452
InnateDB Gene IDBG-102982 (PMVK)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Peroxisome {ECO:0000269PubMed:10191291}.
Disease Associations
Tissue Specificity Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung. {ECO:0000269PubMed:8663599}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004631 phosphomevalonate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0044281 small molecule metabolic process
GO:0070723 response to cholesterol
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR005919 Higher eukaryotic phosphomevalonate kinase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF04275
PRINTS
PIRSF PIRSF036639
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15126
PhosphoSite PhosphoSite-Q15126
TrEMBL Q6FGV9
UniProt Splice Variant
Entrez Gene 10654
UniGene Hs.30954
RefSeq NP_006547
HUGO HGNC:9141
OMIM 607622
CCDS CCDS1073
HPRD 07404
IMGT
EMBL AF026069 AK312803 BC006089 BC007694 BT019976 CH471121 CR541998 L77213
GenPept AAC37593 AAC60791 AAH06089 AAH07694 AAV38779 BAG35661 CAG46795 EAW53177 EAW53178

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca