Homo sapiens Gene: PMVK
Summary
InnateDB Gene IDBG-102982.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PMVK
Gene Name phosphomevalonate kinase
Synonyms HUMPMKI; PMK; PMKA; PMKASE;
Species Homo sapiens
Ensembl Gene ENSG00000163344
Encoded Proteins
phosphomevalonate kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:154924734-154936991
Strand Reverse strand
Band q21.3
Transcripts
ENST00000368467 ENSP00000357452
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 10 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004631 phosphomevalonate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0044281 small molecule metabolic process
GO:0070723 response to cholesterol
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Activation of gene expression by SREBF (SREBP) pathway
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
Metabolism pathway
KEGG
Terpenoid backbone biosynthesis pathway
Peroxisome pathway
INOH
Steroids metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q15126
TrEMBL Q6FGV9
UniProt Splice Variant
Entrez Gene 10654
UniGene Hs.30954
RefSeq NM_006556
HUGO HGNC:9141
OMIM 607622
CCDS CCDS1073
HPRD 07404
IMGT
EMBL AF026069 AK312803 BC006089 BC007694 BT019976 CH471121 CR541998 L77213
GenPept AAC37593 AAC60791 AAH06089 AAH07694 AAV38779 BAG35661 CAG46795 EAW53177 EAW53178
RNA Seq Atlas 10654