InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FDPS

Summary

InnateDB Protein

IDBP-103241.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FDPS

Protein Name

farnesyl diphosphate synthase

Synonyms

FPPS; FPS;

Species

Homo sapiens

Ensembl Protein

ENSP00000357340

InnateDB Gene

IDBG-103239 (FDPS)

Protein Structure

UniProt Annotation

Function

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004161	dimethylallyltranstransferase activity
GO:0004337	geranyltranstransferase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006695	cholesterol biosynthetic process
GO:0008299	isoprenoid biosynthetic process
GO:0016032	viral process
GO:0033384	geranyl diphosphate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0045337	farnesyl diphosphate biosynthetic process