Version 5.4
Homo sapiens Gene: FDPS
Summary
InnateDB Gene IDBG-103239.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FDPS
Gene Name farnesyl diphosphate synthase
Synonyms FPPS; FPS
Species Homo sapiens
Ensembl Gene ENSG00000160752
Encoded Proteins
IDBP-103241
farnesyl diphosphate synthase
IDBP-103243
farnesyl diphosphate synthase
IDBP-388914
farnesyl diphosphate synthase
IDBP-810435
farnesyl diphosphate synthase
IDBP-810433
farnesyl diphosphate synthase
IDBP-810438
farnesyl diphosphate synthase
IDBP-810439
farnesyl diphosphate synthase
IDBP-810440
farnesyl diphosphate synthase
IDBP-810445
farnesyl diphosphate synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155308748-155320666
Strand Forward strand
Band q22
Transcripts
ENST00000368356 ENSP00000357340
ENST00000356657 ENSP00000349078
ENST00000447866 ENSP00000391755
ENST00000468479
ENST00000461507
ENST00000467076 ENSP00000480142
ENST00000474345 ENSP00000478032
ENST00000471117
ENST00000495308
ENST00000491013 ENSP00000479557
ENST00000487002
ENST00000465559 ENSP00000484099
ENST00000470171
ENST00000489003
ENST00000477057
ENST00000492887
ENST00000492244
ENST00000490140
ENST00000489324
ENST00000612683 ENSP00000478235
ENST00000611010 ENSP00000483188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004161 dimethylallyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0008299 isoprenoid biosynthetic process
GO:0016032 viral process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000059743
View Gene Order
Pathways
NETPATH
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2224
UniGene
RefSeq NM_001242825 NM_001135821 NM_001135822 NM_001242824 NM_002004 XM_005244962 XM_005244963
HUGO HGNC:3631
OMIM 134629
CCDS CCDS72940 CCDS1110 CCDS44241
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 2224

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca