InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RUSC1

Summary

InnateDB Protein

IDBP-103251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUSC1

Protein Name

RUN and SH3 domain containing 1

Synonyms

NESCA;

Species

Homo sapiens

Ensembl Protein

ENSP00000357336

InnateDB Gene

IDBG-103247 (RUSC1)

Protein Structure

UniProt Annotation

Function

Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. {ECO:0000269PubMed:19365808}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Translocated to the nuclear envelope upon stimulation with NGF. Associated with membranes and microtubules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0009967	positive regulation of signal transduction
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0014069	postsynaptic density
GO:0015630	microtubule cytoskeleton
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0031410	cytoplasmic vesicle
GO:0045211	postsynaptic membrane