Version 5.4
Homo sapiens Gene: RUSC1
Summary
InnateDB Gene IDBG-103247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RUSC1
Gene Name RUN and SH3 domain containing 1
Synonyms NESCA
Species Homo sapiens
Ensembl Gene ENSG00000160753
Encoded Proteins
IDBP-103249
RUN and SH3 domain containing 1
IDBP-103251
RUN and SH3 domain containing 1
IDBP-103255
RUN and SH3 domain containing 1
IDBP-103257
RUN and SH3 domain containing 1
IDBP-103259
RUN and SH3 domain containing 1
IDBP-809889
RUN and SH3 domain containing 1
IDBP-809895
RUN and SH3 domain containing 1
IDBP-809922
RUN and SH3 domain containing 1
IDBP-809924
RUN and SH3 domain containing 1
IDBP-809925
RUN and SH3 domain containing 1
IDBP-809926
RUN and SH3 domain containing 1
IDBP-809928
RUN and SH3 domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19365808
RUSC1 binds to IKBKG and TRAF6, representing a molecular link between NGF signalling and IKK complex activity.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:155320896-155331114
Strand Forward strand
Band q22
Transcripts
ENST00000368354 ENSP00000357338
ENST00000368352 ENSP00000357336
ENST00000368349 ENSP00000357333
ENST00000368347 ENSP00000357331
ENST00000292254 ENSP00000292254
ENST00000467820
ENST00000497930 ENSP00000479858
ENST00000489860 ENSP00000479495
ENST00000462780
ENST00000492536
ENST00000490373 ENSP00000484026
ENST00000479924 ENSP00000480831
ENST00000468764 ENSP00000482109
ENST00000471876 ENSP00000482409
ENST00000473331
ENST00000485924 ENSP00000481669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0009967 positive regulation of signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005874 microtubule
GO:0014069 postsynaptic density
GO:0015630 microtubule cytoskeleton
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000041263
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.226499
RefSeq NM_001105203 NM_001105204 NM_001105205 NM_001278227 NM_001278228 NM_001278229 NM_001278230 NM_014328 XM_006711258
HUGO
OMIM
CCDS CCDS1112 CCDS41410 CCDS41411 CCDS41412
HPRD 10206
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca