Homo sapiens Protein: RUSC1
Summary
InnateDB Protein IDBP-103255.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RUSC1
Protein Name RUN and SH3 domain containing 1
Synonyms NESCA;
Species Homo sapiens
Ensembl Protein ENSP00000357333
InnateDB Gene IDBG-103247 (RUSC1)
Protein Structure
UniProt Annotation
Function Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. {ECO:0000269PubMed:19365808}.
Subcellular Localization Cytoplasm. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Early endosome {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Translocated to the nuclear envelope upon stimulation with NGF. Associated with membranes and microtubules (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0009967 positive regulation of signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005874 microtubule
GO:0014069 postsynaptic density
GO:0015630 microtubule cytoskeleton
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR004012 RUN
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF02759
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00593
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BVN2
PhosphoSite PhosphoSite-Q9BVN2
TrEMBL Q68CX2
UniProt Splice Variant
Entrez Gene 23623
UniGene Hs.226499
RefSeq NP_055143
HUGO HGNC:17153
OMIM
CCDS CCDS1112
HPRD 10206
IMGT
EMBL AB026894 AK055451 AK074982 AK125378 AK314559 AL080083 AL139410 BC001045 BC025680 BC052277 BX640612 CH471121 CR749671
GenPept AAH01045 AAH52277 BAA77507 BAG37144 BAG52045 BAG54191 CAB45702 CAE45718 CAH18462 EAW53069 EAW53071 EAW53072