InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SH2D2A

Summary

InnateDB Protein

IDBP-103629.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SH2D2A

Protein Name

SH2 domain containing 2A

Synonyms

F2771; SCAP; TSAD; VRAP;

Species

Homo sapiens

Ensembl Protein

ENSP00000357182

InnateDB Gene

IDBG-103627 (SH2D2A)

Protein Structure

UniProt Annotation

Function

Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, small intestine, and colon. Expressed at low levels in unstimulated T-cells, but not expressed in normal resting or activated B-cells. According to PubMed:10692392, expression is not restricted to activated T-cells, but strongly expressed in blood cell lineages, the endothelium and other cell and tissue types, such as heart, lung, and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.