InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ETV3

Summary

InnateDB Protein

IDBP-103664.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ETV3

Protein Name

ets variant 3

Synonyms

bA110J1.4; METS; PE-1; PE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000327316

InnateDB Gene

IDBG-103660 (ETV3)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. {ECO:0000269PubMed:12007404}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00237}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003674	molecular_function
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0008150	biological_process
GO:0030154	cell differentiation