Version 5.4
Homo sapiens Protein: CD5L
Summary
InnateDB Protein IDBP-103718.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD5L
Protein Name CD5 molecule-like
Synonyms AIM; API6; PRO229; SP-ALPHA; Spalpha;
Species Homo sapiens
Ensembl Protein ENSP00000357156
InnateDB Gene IDBG-103716 (CD5L)
Protein Structure
UniProt Annotation
Function May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues. {ECO:0000269PubMed:9045627}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0006915 apoptotic process
GO:0006968 cellular defense response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR001190 SRCR domain
IPR017448 SRCR-like domain
PFAM PF00530
PRINTS PR00258
PIRSF
SMART SM00202
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O43866
PhosphoSite PhosphoSite-O43866
TrEMBL
UniProt Splice Variant
Entrez Gene 922
UniGene Hs.134035
RefSeq NP_005885
HUGO HGNC:1690
OMIM 602592
CCDS CCDS1171
HPRD 03997
IMGT
EMBL AF011429 AK292040 AL139409 AY358494 BC033586 CH471121 U82812
GenPept AAB91989 AAD01446 AAH33586 AAQ88858 BAF84729 CAC19458 EAW52859

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca