Version 5.4
Homo sapiens Protein: CD1C
Summary
InnateDB Protein IDBP-103741.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD1C
Protein Name CD1c molecule
Synonyms BDCA1; CD1; CD1A; R7;
Species Homo sapiens
Ensembl Protein ENSP00000357152
InnateDB Gene IDBG-103739 (CD1C)
Protein Structure
UniProt Annotation
Function Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269PubMed:10786796, ECO:0000269PubMed:10890914, ECO:0000269PubMed:10899914, ECO:0000269PubMed:21167756}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes.
Disease Associations
Tissue Specificity Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030883 endogenous lipid antigen binding
GO:0030884 exogenous lipid antigen binding
GO:0051861 glycolipid binding
GO:0071723 lipopeptide binding
Biological Process
GO:0002286 T cell activation involved in immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0010008 endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein
PFAM PF07654
PRINTS
PIRSF
SMART SM00407
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P29017
PhosphoSite PhosphoSite-
TrEMBL B4DP91
UniProt Splice Variant
Entrez Gene 911
UniGene Hs.132448
RefSeq NP_001756
HUGO HGNC:1636
OMIM 188340
CCDS CCDS1175
HPRD 01772
IMGT
EMBL AF142667 AK298234 AL121986 BC126465 BC126467 CR457080 M14667 M22174 M22175 M22176 M22177 M22178 M28827
GenPept AAA51938 AAA51941 AAA51942 AAD37580 AAI26466 AAI26468 BAG60503 CAG33361 CAI10850

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca