InnateDB Protein
|
IDBP-103765.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CD1E
|
Protein Name
|
CD1e molecule
|
Synonyms
|
CD1A; R2;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000357138
|
InnateDB Gene
|
IDBG-103747 (CD1E)
|
Protein Structure
|
|
Function |
T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane- associated form is not active. {ECO:0000269PubMed:10948205, ECO:0000269PubMed:16311334, ECO:0000269PubMed:21788486}.
|
Subcellular Localization |
T-cell surface glycoprotein CD1e, membrane- associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.T-cell surface glycoprotein CD1e, soluble: Lysosome lumen.
|
Disease Associations |
|
Tissue Specificity |
Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues. {ECO:0000269PubMed:10948205}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
1
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR003597
Immunoglobulin C1-set
IPR007110
Immunoglobulin-like domain
IPR011162
MHC classes I/II-like antigen recognition protein
|
PFAM |
PF07654
|
PRINTS |
|
PIRSF |
|
SMART |
SM00407
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P15812
|
PhosphoSite |
PhosphoSite-P15812
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
913
|
UniGene |
|
RefSeq |
NP_001172044
|
HUGO |
HGNC:1638
|
OMIM |
188411
|
CCDS |
CCDS53386
|
HPRD |
01781
|
IMGT |
|
EMBL |
AF142669
AH010757
AH010758
AJ251334
AJ251335
AJ289111
AJ289112
AJ289113
AJ289114
AJ289115
AJ289116
AJ289117
AJ289118
AJ289119
AJ289120
AJ289121
AJ289122
AK303108
AK311643
AL121986
CH471121
M14666
X14975
|
GenPept |
AAA51937
AAD37582
AAK52913
AAK52914
BAG64215
CAA33100
CAB82829
CAB93150
CAB93151
CAB93152
CAB93153
CAB93154
CAB93155
CAB93156
CAB93157
CAB93158
CAB93159
CAB93160
CAB93161
CAC07175
CAI10854
CAI10855
CAI10856
CAI10857
CAI10858
CAI10859
CAI10860
CAI10861
CAI10862
CAI10863
CAI10864
CAI10865
EAW52828
EAW52830
EAW52831
EAW52832
EAW52833
EAW52834
EAW52835
EAW52837
EAW52838
EAW52839
EAW52840
|
|
|