Homo sapiens Gene: CD1E
InnateDB Gene IDBG-103747.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD1E
Gene Name CD1e molecule
Synonyms CD1A; R2
Species Homo sapiens
Ensembl Gene ENSG00000158488
Encoded Proteins
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
CD1e molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:158353696-158357553
Strand Forward strand
Band q23.1
ENST00000368167 ENSP00000357149
ENST00000368166 ENSP00000357148
ENST00000368165 ENSP00000357147
ENST00000368164 ENSP00000357146
ENST00000368163 ENSP00000357145
ENST00000368162 ENSP00000357144
ENST00000368161 ENSP00000357143
ENST00000368160 ENSP00000357142
ENST00000368156 ENSP00000357138
ENST00000368155 ENSP00000357137
ENST00000368154 ENSP00000357136
ENST00000368157 ENSP00000357139
ENST00000452291 ENSP00000416228
ENST00000444681 ENSP00000402906
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0000139 Golgi membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005887 integral component of plasma membrane
GO:0043202 lysosomal lumen
No orthologs found for this gene
Hematopoietic cell lineage pathway
SwissProt P15812
TrEMBL Q13974
UniProt Splice Variant
Entrez Gene 913
RefSeq NM_001042583 NM_001042584 NM_001042585 NM_001042586 NM_001042587 NM_001185107 NM_001185108 NM_001185110 NM_001185112 NM_001185113 NM_001185114 NM_001185115 NM_030893
OMIM 188411
CCDS CCDS41417 CCDS41418 CCDS41419 CCDS41420 CCDS41421 CCDS41422 CCDS53384 CCDS53385 CCDS53386 CCDS53387 CCDS53388 CCDS53389 CCDS53390
EMBL AF142669 AH010757 AH010758 AJ251334 AJ251335 AJ289111 AJ289112 AJ289113 AJ289114 AJ289115 AJ289116 AJ289117 AJ289118 AJ289119 AJ289120 AJ289121 AJ289122 AK303108 AK311643 AL121986 CH471121 M14666 X14975 X79519
GenPept AAA51937 AAD37582 AAK52913 AAK52914 BAG64215 CAA33100 CAA56055 CAB82829 CAB93150 CAB93151 CAB93152 CAB93153 CAB93154 CAB93155 CAB93156 CAB93157 CAB93158 CAB93159 CAB93160 CAB93161 CAC07175 CAI10854 CAI10855 CAI10856 CAI10857 CAI10858 CAI10859 CAI10860 CAI10861 CAI10862 CAI10863 CAI10864 CAI10865 EAW52828 EAW52830 EAW52831 EAW52832 EAW52833 EAW52834 EAW52835 EAW52837 EAW52838 EAW52839 EAW52840
RNA Seq Atlas 913