Version 5.4
Homo sapiens Protein: CD1E
Summary
InnateDB Protein IDBP-103769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD1E
Protein Name CD1e molecule
Synonyms CD1A; R2;
Species Homo sapiens
Ensembl Protein ENSP00000357136
InnateDB Gene IDBG-103747 (CD1E)
Protein Structure
UniProt Annotation
Function T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane- associated form is not active. {ECO:0000269PubMed:10948205, ECO:0000269PubMed:16311334, ECO:0000269PubMed:21788486}.
Subcellular Localization T-cell surface glycoprotein CD1e, membrane- associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.T-cell surface glycoprotein CD1e, soluble: Lysosome lumen.
Disease Associations
Tissue Specificity Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues. {ECO:0000269PubMed:10948205}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008289 lipid binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0000139 Golgi membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005887 integral component of plasma membrane
GO:0043202 lysosomal lumen
Protein Structure and Domains
PDB ID
InterPro IPR003597 Immunoglobulin C1-set
PFAM PF07654
PRINTS
PIRSF
SMART SM00407
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P15812
PhosphoSite PhosphoSite-P15812
TrEMBL Q13974
UniProt Splice Variant
Entrez Gene 913
UniGene
RefSeq NP_001172042
HUGO HGNC:1638
OMIM 188411
CCDS CCDS53388
HPRD 01781
IMGT
EMBL AF142669 AH010757 AH010758 AJ251334 AJ251335 AJ289111 AJ289112 AJ289113 AJ289114 AJ289115 AJ289116 AJ289117 AJ289118 AJ289119 AJ289120 AJ289121 AJ289122 AK303108 AK311643 AL121986 CH471121 M14666 X14975 X79519
GenPept AAA51937 AAD37582 AAK52913 AAK52914 BAG64215 CAA33100 CAA56055 CAB82829 CAB93150 CAB93151 CAB93152 CAB93153 CAB93154 CAB93155 CAB93156 CAB93157 CAB93158 CAB93159 CAB93160 CAB93161 CAC07175 CAI10854 CAI10855 CAI10856 CAI10857 CAI10858 CAI10859 CAI10860 CAI10861 CAI10862 CAI10863 CAI10864 CAI10865 EAW52828 EAW52830 EAW52831 EAW52832 EAW52833 EAW52834 EAW52835 EAW52837 EAW52838 EAW52839 EAW52840

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca