Version 5.4
Homo sapiens Protein: IFI16
Summary
InnateDB Protein IDBP-103854.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFI16
Protein Name interferon, gamma-inducible protein 16
Synonyms IFNGIP1; PYHIN2;
Species Homo sapiens
Ensembl Protein ENSP00000352740
InnateDB Gene IDBG-103852 (IFI16)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 20 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001819 positive regulation of cytokine production
GO:0002218 activation of innate immune response
GO:0006351 transcription, DNA-templated
GO:0006914 autophagy
GO:0006954 inflammatory response
GO:0008283 cell proliferation
GO:0010506 regulation of autophagy
GO:0030097 hemopoiesis
GO:0030099 myeloid cell differentiation
GO:0030224 monocyte differentiation
GO:0032481 positive regulation of type I interferon production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0042149 cellular response to glucose starvation
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043392 negative regulation of DNA binding
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045824 negative regulation of innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0071479 cellular response to ionizing radiation
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097202 activation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR004020 DAPIN domain
IPR004021 HIN-200/IF120x
IPR011029 Death-like domain
PFAM PF02758
PF02760
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16666
PhosphoSite PhosphoSite-Q16666
TrEMBL H3BVE6
UniProt Splice Variant
Entrez Gene 3428
UniGene Hs.629190
RefSeq NP_001193496
HUGO HGNC:5395
OMIM 147586
CCDS CCDS58039
HPRD 00969
IMGT
EMBL AB208989 AF208043 AK094968 AK296228 AL359753 AY138863 BC017059 M63838 S75417 S75419 S75421 S75423 S75424 S75426 S75429 S75431 S75433
GenPept AAA58683 AAB32519 AAF20997 AAH17059 AAM96005 BAC04462 BAD92226 BAG58950 CAI15081 CAI15082 CAI15083 CAI15084 CAI15085 CAI15086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca