Version 5.4
Homo sapiens Protein: DARC
Summary
InnateDB Protein IDBP-103874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DARC
Protein Name Duffy blood group, chemokine receptor
Synonyms CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1;
Species Homo sapiens
Ensembl Protein ENSP00000357104
InnateDB Gene IDBG-246055 (DARC)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0019957 C-C chemokine binding
Biological Process
GO:0006952 defense response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro IPR005384 Duffy antigen/chemokine receptor
PFAM
PRINTS PR01559
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16570
PhosphoSite PhosphoSite-
TrEMBL Q5Y7A2
UniProt Splice Variant
Entrez Gene 2532
UniGene Hs.153381
RefSeq NP_002027
HUGO HGNC:4035
OMIM 613665
CCDS CCDS1183
HPRD 00192
IMGT
EMBL AF030521 AF055992 AF100634 AK291593 AL035403 AM887935 AY663418 BC017817 DQ181554 DQ181556 DQ181557 DQ181558 DQ181559 DQ181560 DQ181561 DQ181562 DQ181567 JN251907 JN251908 JN251909 S76830 U01839 X85785
GenPept AAB33239 AAC50055 AAC72301 AAD20435 AAF02415 AAF02416 AAH17817 AAU47281 ABA10406 ABA10412 ABA10415 ABA10418 ABA10421 ABA10424 ABA10427 ABA10430 ABA10445 AET81018 AET81019 AET81021 BAF84282 CAA59770 CAB56228 CAP12644

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca