InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DARC

Summary

InnateDB Protein

IDBP-103878.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DARC

Protein Name

Duffy blood group, chemokine receptor

Synonyms

CCBP1; CD234; DARC; Dfy; FY; GPD; GpFy; WBCQ1;

Species

Homo sapiens

Ensembl Protein

ENSP00000357103

InnateDB Gene

IDBG-246055 (DARC)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0019956	chemokine binding
GO:0019957	C-C chemokine binding

Biological Process

GO:0006952	defense response
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0032642	regulation of chemokine production
GO:0070098	chemokine-mediated signaling pathway

Cellular Component

GO:0005769	early endosome
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0055037	recycling endosome

Protein Structure and Domains

PDB ID

InterPro

IPR005384 Duffy antigen/chemokine receptor

PFAM

PRINTS

PR01559

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF030521 AF055992 AF100634 AL035403 AM887935 AY663418 BC017817 BC095496 DQ181554 DQ181556 DQ181557 DQ181558 DQ181559 DQ181560 DQ181561 DQ181562 DQ181567 JN251907 JN251908 JN251909 S76830 U01839 X85785

GenPept

AAB33239 AAC50055 AAC72301 AAD20435 AAF02415 AAF02416 AAH17817 AAH95496 AAU47282 ABA10407 ABA10413 ABA10416 ABA10419 ABA10422 ABA10425 ABA10428 ABA10431 ABA10446 AET81017 AET81020 AET81022 CAA59770 CAB56228 CAP12644

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca