Homo sapiens Protein: COPA | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-104031.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | COPA | ||||||||||||||||||||||
Protein Name | coatomer protein complex, subunit alpha | ||||||||||||||||||||||
Synonyms | HEP-COP; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000357048 | ||||||||||||||||||||||
InnateDB Gene | IDBG-104029 (COPA) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.Xenin: Secreted {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR001680
WD40 repeat IPR006692 Coatomer, WD associated region IPR010714 Coatomer, alpha subunit, C-terminal IPR016391 Coatomer alpha subunit IPR017986 WD40-repeat-containing domain IPR020472 G-protein beta WD-40 repeat |
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PFAM |
PF00400
PF04053 PF06957 |
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PRINTS |
PR00320
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PIRSF |
PIRSF003354
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SMART |
SM00320
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P53621 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P53621 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 1314 | ||||||||||||||||||||||
UniGene | Hs.656374 | ||||||||||||||||||||||
RefSeq | NP_001091868 | ||||||||||||||||||||||
HUGO | HGNC:2230 | ||||||||||||||||||||||
OMIM | 601924 | ||||||||||||||||||||||
CCDS | CCDS41424 | ||||||||||||||||||||||
HPRD | 03564 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AL445230 AL513282 BC038447 CH471121 U24105 | ||||||||||||||||||||||
GenPept | AAB70879 AAH38447 CAI12454 CAI12455 CAI15004 CAI15005 EAW52723 EAW52725 | ||||||||||||||||||||||