InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COPA

Summary

InnateDB Protein

IDBP-104033.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COPA

Protein Name

coatomer protein complex, subunit alpha

Synonyms

HEP-COP;

Species

Homo sapiens

Ensembl Protein

ENSP00000241704

InnateDB Gene

IDBG-104029 (COPA)

Protein Structure

UniProt Annotation

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.Xenin: Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER
GO:0016192	vesicle-mediated transport
GO:0030157	pancreatic juice secretion
GO:0048205	COPI coating of Golgi vesicle
GO:0061024	membrane organization

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030126	COPI vesicle coat
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001680 WD40 repeat
IPR006692 Coatomer, WD associated region
IPR010714 Coatomer, alpha subunit, C-terminal
IPR016391 Coatomer alpha subunit
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF04053
PF06957

PRINTS

PR00320

PIRSF

PIRSF003354

SMART

SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References