InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLAMF1

Summary

InnateDB Protein

IDBP-104077.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLAMF1

Protein Name

signaling lymphocytic activation molecule family member 1

Synonyms

CD150; CDw150; SLAM;

Species

Homo sapiens

Ensembl Protein

ENSP00000235739

InnateDB Gene

IDBG-104073 (SLAMF1)

Protein Structure

UniProt Annotation

Function

High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Note=Present on the surface of B-cells and T-cells.

Disease Associations

Tissue Specificity

Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0016032	viral process
GO:0045087	innate immune response (InnateDB)
GO:0046649	lymphocyte activation