InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLAMF7

Summary

InnateDB Protein

IDBP-104092.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLAMF7

Protein Name

SLAM family member 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357021

InnateDB Gene

IDBG-104088 (SLAMF7)

Protein Structure

UniProt Annotation

Function

Isoform 1 mediates NK cell activation through a SH2D1A- independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion.Isoform 3 does not mediate any NK cell activation.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at much lower level than isoform 1. {ECO:0000269PubMed:11220635, ECO:0000269PubMed:11698418, ECO:0000269PubMed:11802771, ECO:0000269PubMed:12242590}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0030101	natural killer cell activation
GO:0042267	natural killer cell mediated cytotoxicity
GO:0045087	innate immune response (InnateDB)