InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS4

Summary

InnateDB Protein

IDBP-104430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS4

Protein Name

regulator of G-protein signaling 4

Synonyms

RGP4; SCZD9;

Species

Homo sapiens

Ensembl Protein

ENSP00000356885

InnateDB Gene

IDBG-104428 (RGS4)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

Subcellular Localization

Disease Associations

Schizophrenia 9 (SCZD9) [MIM:604906]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269PubMed:12023979, ECO:0000269PubMed:14755443}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. {ECO:0000269PubMed:17707117}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	17 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005516	calmodulin binding

Biological Process

GO:0000188	inactivation of MAPK activity
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway