InnateDB Protein
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IDBP-104432.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RGS4
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Protein Name
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regulator of G-protein signaling 4
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Synonyms
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RGP4; SCZD9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000356884
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InnateDB Gene
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IDBG-104428 (RGS4)
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Protein Structure
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Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
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Subcellular Localization |
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Disease Associations |
Schizophrenia 9 (SCZD9) [MIM:604906]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269PubMed:12023979, ECO:0000269PubMed:14755443}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
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Tissue Specificity |
Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. {ECO:0000269PubMed:17707117}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000188
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inactivation of MAPK activity
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GO:0008277
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regulation of G-protein coupled receptor protein signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P49798
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5999
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UniGene |
Hs.714067
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RefSeq |
NP_001106852
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HUGO |
HGNC:10000
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OMIM |
602516
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CCDS |
CCDS44271
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HPRD |
03947
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IMGT |
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EMBL |
AF493928
AK093959
AK295540
AK296240
AK312250
AL583850
BC000737
BC051869
BT007025
CH471067
DQ346662
DQ346663
DQ346664
EF054877
U27768
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GenPept |
AAC50395
AAH00737
AAH51869
AAM12642
AAP35671
ABC94590
ABC94591
ABC94592
ABL74968
BAG35182
BAG58449
BAG58958
CAH73766
CAH73767
CAH73768
EAW90727
EAW90728
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