InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MGST3

Summary

InnateDB Protein

IDBP-104481.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MGST3

Protein Name

microsomal glutathione S-transferase 3

Synonyms

GST-III;

Species

Homo sapiens

Ensembl Protein

ENSP00000356859

InnateDB Gene

IDBG-104471 (MGST3)

Protein Structure

UniProt Annotation

Function

Also functions as a glutathione peroxidase.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	9 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004601	peroxidase activity
GO:0004602	glutathione peroxidase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006805	xenobiotic metabolic process
GO:0007165	signal transduction
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process
GO:1901687	glutathione derivative biosynthetic process

Cellular Component

GO:0005635	nuclear envelope
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome