Homo sapiens Gene: MGST3
Summary
InnateDB Gene IDBG-104471.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MGST3
Gene Name microsomal glutathione S-transferase 3
Synonyms GST-III;
Species Homo sapiens
Ensembl Gene ENSG00000143198
Encoded Proteins
microsomal glutathione S-transferase 3
microsomal glutathione S-transferase 3
microsomal glutathione S-transferase 3
microsomal glutathione S-transferase 3
microsomal glutathione S-transferase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:165630861-165661796
Strand Forward strand
Band q24.1
Transcripts
ENST00000367889 ENSP00000356864
ENST00000367888 ENSP00000356863
ENST00000367885 ENSP00000356860
ENST00000367884 ENSP00000356859
ENST00000367883 ENSP00000356858
ENST00000461308
ENST00000460632
ENST00000495447
ENST00000488688
ENST00000461759
ENST00000477450
ENST00000494074
ENST00000609263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 9 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0007165 signal transduction
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005635 nuclear envelope
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glutathione conjugation pathway
Aflatoxin activation and detoxification pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Glutathione metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.675411
RefSeq NM_004528 XM_005245174
HUGO
OMIM
CCDS CCDS1249
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas