InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALDH9A1

Summary

InnateDB Protein

IDBP-104486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH9A1

Protein Name

aldehyde dehydrogenase 9 family, member A1

Synonyms

ALDH4; ALDH7; ALDH9; E3; TMABADH;

Species

Homo sapiens

Ensembl Protein

ENSP00000346827

InnateDB Gene

IDBG-104484 (ALDH9A1)

Protein Structure

UniProt Annotation

Function

Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction. {ECO:0000269PubMed:10702312}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain. Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole. {ECO:0000269PubMed:8645224}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity
GO:0004029	aldehyde dehydrogenase (NAD) activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0019145	aminobutyraldehyde dehydrogenase activity
GO:0033737	1-pyrroline dehydrogenase activity
GO:0042803	protein homodimerization activity
GO:0043176	amine binding
GO:0047105	4-trimethylammoniobutyraldehyde dehydrogenase activity
GO:0051287	NAD binding

Biological Process

GO:0001822	kidney development
GO:0001889	liver development
GO:0006081	cellular aldehyde metabolic process
GO:0008152	metabolic process
GO:0009437	carnitine metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042445	hormone metabolic process
GO:0044281	small molecule metabolic process
GO:0045329	carnitine biosynthetic process
GO:0055114	oxidation-reduction process